Advances in finding a vaccine for African swine fever

Publication date: 03/11/2023
Extent: 18 pages

Contributions by: Douglas P. Gladue and Manuel V. Borca, Plum Island Animal Disease Center and Center of Excellence for African Swine Fever Genomics, USA

Chapter synopsis:

The development of a vaccine for African swine fever (ASF) has been an ongoing topic of research in labs worldwide for many years, with increased interest following the 2007 outbreak in the Republic of Georgia. This initial outbreak has since spread causing continued outbreaks in Europe, Asia and most recently in the Dominican Republic and Haiti. Recently a live-attenuated vaccine was approved and is the only commercially produced vaccine for ASF only approved for use in Vietnam. It remains that there is not a widely available commercial vaccine for countries suffering outbreaks of ASF in this chapter we will present how we were able to develop this vaccine, and how it became the lead candidate vaccine for ASF. Without a vaccine disease management for this current pandemic has been limited to restricting animal movement and culling of infected animals or farms. In this chapter the current state of ASF vaccine research is presented covering all published reports on subunit vaccines, naturally or cell culture passed viruses used as attenuated vaccine backbones, and live attenuated vaccines using targeted deletions in virulent ASFV isolates.

DOI: 10.19103/9781786768629.04