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Peptides as novel biopesticides

Code: 9781786767097
Publication date: 23/03/2020
Extent: 18 pages

Contributions by: Lin Bao, Robert M. Kennedy, Kyle Schneider, Alvar Carlson and Andy Renz, Vestaron Corporation, USA

Chapter synopsis: Venom peptides are small toxic proteins originated from animal venoms. They have attracted great interest as a route to develop the next generation of novel, effective and safe biopesticides. This chapter reviews the characteristics and discovery of a range of venom peptides. It shows how inhibitory cysteine knot (ICK) type peptides, characterized by strong selectivity/specificity, stability and capacity for production at high volume, were used to develop the first commercialised peptide-based insecticide: SPEAR®. It also discusses other commercialised peptides and techniques to incorporate venom into plants to protect against insect and fungal attack.

DOI: 10.19103/AS.2020.0073.14
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Table of contents 1 Introduction 2 Venom peptides as biopesticides 3 The discovery of novel venom peptides 4 The first commercialized venom peptide-based biopesticide: SPEAR® 5 Other commercialized peptides: harpin and trypsin modulating oostatic factor (TMOF) 6 Plant expression of venom peptides 7 Plant defensin and other antifungal peptides 8 Summary and future trends 9 References

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