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Advances in understanding the role of plant phytochemicals in preventing cancer

Code: 9781801465625
Publication date: 29/08/2022
Extent: 24 pages

Contributions by: Gulsun Akdemir Evrendilek, Bolu Abant Izzet Baysal University, Turkey

Chapter synopsis: Increased incidences of cancer caused by dysregulated gene expression or dysfunctional genes, in addition to the side effects of chemo- and radio-therapies, have led to studies featuring more natural treatments. Various natural compounds, also called cancer-preventive, and/or phytochemicals possessing significant anticancer properties, are now in demand as an alternative to traditional cancer treatments, although their low selectivity may limit their use. New approaches involving encapsulation, micelle formation, coating as nano- and micro- particles, and combined use of phytochemicals to increase their diffusion through different delivery systems with their anticancer properties against various types of cancer are proving very promising. Phytochemicals, their mode of action, current studies to accelerate their effectiveness, and future trends are summarized in this chapter.

DOI: 10.19103/AS.2022.0101.08
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Table of contents 1 Introduction 2 Importance of plant-based foods 3 Mechanisms of chemoprevention 4 Phytochemicals and their mode of action 5 Cancer-preventive effects of antioxidant and anti-inflammatory activities 6 Angiogenesis suppression activities of phytochemicals 7 Functions of phytochemicals in cell death pathway regulation 8 Combined use of phytochemicals with antineoplastic agents 9 Importance of delivery systems for phytochemicals 10 Routes of administration for phytochemicals 11 Combining phytochemicals with other applications 12 Conclusion 13 Where to look for further information 14 References

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